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Semaglutide Starting Dose for Weight Loss Weeks 14: 0.25 mg subcutaneous injection weekly Weeks 58: Increase to 0.5 mg Weeks 912: 1 mg Maintenance: 1.72.4 mg weekly, depending on tolerance and results Best Time of Day to Take Semaglutide for Weight Loss Can be taken anytime, with or without food Consistency matters (e.g., same day weekly, like take on Monday mornings) Follow provider guidance for maximum results Duration of Therapy Typical use spans 68 weeks to 2 years for peak weight loss Maintenance may continue indefinitely to prevent regain Stopping prematurely can lead to weight rebound in up to two-thirds of patients Pros and Cons of Semaglutide Semaglutide offers compelling benefits but there are some considerations: Wegovy trials report significant weight loss and improved metabolic markers compared to placebo