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The broader benefits of GLP-1 therapyincluding improvements in body composition, insulin resistance, cardiovascular risk factors, sleep apnea, and overall metabolic healthcan all positively influence reproductive function. Because infertility, obesity, metabolic syndrome, and low testosterone frequently coexist, treating the underlying metabolic disease may have substantial downstream reproductive benefits

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Thus we proposed the central idea of our commentary: Chronic glucagon suppression may shift amino-acid handling toward muscle proteolysis, creating a silent but progressive erosion of muscle reserve

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