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2019;29:3580-3591.e3584

Network analysis Analysis of inferred protein:protein interaction (PPI) networks was performed using Ingenuity Pathways Analysis software to increase confidence in the observations of differentially expressed genes by their correlation with biological pathways

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We next examined a downstream effect of sustained mitochondrial damage by measuring cytosolic levels of apoptosis-inducing factor (AIF), a mitochondrial endonuclease that is released after the mitochondrial permeability transition and contributes to DNA fragmentation during necrotic cell death

Comhair SA, Thomassen MJ, Erzurum SC: Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke