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Moreover, simplified experimental paradigms often fail to capture the complex, multifactorial nature of human neurodegeneration, including chronic inflammation, metabolic dysfunction, and cumulative injury [569571]

Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies

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When performed by experienced surgeons in expert centers, discoid excision is considered safe, with postoperative complication rates of 24.5% (mostly minor Clavien-Dindo grades I-II) and no severe complications like rectovaginal fistula or anastomotic leakage reported (60)

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