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By disrupting the vicious cycle of NLRP3 activation and mitochondrial dysfunction, Nrf2 establishes a neuroprotective barrier against synergistic inflammatory and oxidative insults (Rajan et al., 2023

They can also prescribe medications, like topical creams, that may make a difference

Moreover, potential health benefits, such as improved metabolic flexibility and immuno-and neuroprotection, are associated with PQQ supplementation

Presumably, GABA-B receptor positive allosteric agents are anxiolytic whereas the antagonists could be antidepressants (75)

Arch Dermatol Res 301(6):449457