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[PMC free article: PMC323028] [PubMed: 3456567] 206

In the 1980s, researchers studying this reptile's saliva discovered a peptide called exendin-4 that would eventually lead to the development of GLP-1 receptor agonistsa class of medications now used by millions seeking sustainable weight loss

Major medical organizations including the American College of Obstetricians and Gynecologists have not issued absolute contraindications against GLP-1 medications during breastfeeding, but they emphasize the importance of individualized medical judgment

In the TRIUMPH-4 phase 3 trial, 445 adults with overweight or obesity and knee osteoarthritis were randomly assigned, 1:1:1, to receive 9 mg retatrutide, 12 mg retatrutide or placebo for 68 weeks

Accessed June 7, 2023