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This hypothesis is further supported by our mutagenesis analysis that substituting F279 6.51 and F312 7.42 with alanine dramatically diminishes the basal activity of ghrelin receptor (Supplementary Fig

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(h) a global defect in steroid 5 -reduction as demonstrated by decreased urinary 5 -reduced metabolites of both C21 steroids and C19 steroids other than testosterone, i.e