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Moreover, the ferroptotic pathway analysis revealed an enrichment of ferroptosis only in SUM-159 and SUM-159-CD36 cells but not in MCF-7 and MCF-7-CD36 cells following PA treatment (Figs

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Fact: Standard oral glutathione is poorly absorbed by the gut

Erastin, a ferroptosis inducer, inhibits the activity of the cystine/glutamate antiporter, blocking the synthesis of glutathione and weakening the cells antioxidant capacity, ultimately leading to ferroptosis