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During the first two to four weeks, participants in trials have reported: Gastrointestinal effects: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort are among the most commonly reported side effects

Rougraff BT, Aboulafia A, Biermann JS, Healey J

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Semin Cutan Med Surg (2009) 28:15764

Some individuals report improvement in chronic conditions, while others note rashes or nonspecific irritation

For people who cant tolerate injections or who strongly prefer oral medication, Rybelsus remains a reasonable option for managing type 2 diabetes