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Therefore, contrary to the traditional approaches, these changes could be explained as the result of ammonium detoxification driven by increased glutamine synthesis from glutamate in astrocytes, without necessarily affecting neurotransmission at late stages of the disease

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Finally, the PLB dosage and administration strategy should be refined, and its long-term effects and potential side effects should be comprehensively evaluated to confirm its safety and effectiveness in clinical applications

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doi:10.1146/annurev.bi.52.070183.003431