This functional improvement was associated with intermediate-conductance Ca 2+ -activated K + channels (KCa3.1) via the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MEK/ERK) and phosphoinositide 3-kinases (PI3K), serine/threonine protein kinase B (PKB
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Several studies demonstrated IL-6 to regulate glucose tolerance and insulin action (107, 108) and furthermore, IL-6 was shown to enhance insulin secretion by increasing GLP-1 production in L cells and alpha cells, leading to improved glucose tolerance (109)
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Evidence suggests that VSMC ferroptosis may help enhance atherosclerotic lesions
The SDF-1/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells