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It has been shown that SIRT1 prevents the development of endothelial dysfunction through attenuation progression of oxidative stress by multiple mechanisms including SIRT1/SOD, SIRT1/FOXO, SIRT1/eNOs, and SIRT1/NF-B (Kang et al

This happens because the body adapts to the mechanism over time, which may reduce responsiveness

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[70] Other lipoic acids [edit] -lipoic acid is a thiosulfinate of -lipoic acid See also [edit] References [edit] 1 2 3 4 "Lipoic acid"

Cardiovasc Diabetol 19(1):156 International Diabetes Federation (2022) Brussels: International Diabetes Federation