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As per recent studies, the translation of the mRNAs of seleno-GPxs having low priority for selenium utilization (like GPx1) is not favored under low intracellular selenium status due to the interaction of a selenium responsive negative regulator such as eukaryotic initiation factor 4a3 (eIF4a3) with their 3-UTR (Fig

Untreated vitamin B12 deficiency may result in subacute combined degeneration of spinal cord or irreversible neuropathy, which may occur in the absence of megaloblastic anaemia

10.1016/S1474-4422(24)00476-9 21

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Caloric restriction has been shown to extend lifespan and delay the onset of age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast