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[8] [9] This sympathetic activation may be mediated through central nervous system pathways, as GLP-1 receptors are present in the hypothalamus and brainstem regions that regulate cardiovascular function

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FDA noted that the supposed placebo control was an external healthy comparison group rather than a proper concurrent placebo arm

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Maintenance treatments may be advised monthly

Currently, the SURPASS-CVOT trial is evaluating the impact of dulaglutide and tirzepatide on cardiovascular events in patients with T2D (NCT04255433)