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B vitamins are often depleted in individuals with substance abuse, particularly alcohol abuse, due to poor nutritional intake, increased demand for metabolizing substances and poor gastrointestinal absorption

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Differences in embryofetal developmental toxicity from subcutaneously injected exenatide extended-release and exenatide were not evaluated in mice, rats, or rabbits

In addition, they only require once-a-week dosing and have mild side-effect profiles