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The dogs were divided into 3 groups depending on the received dose, including the following 3 doses: 0 mg/day 236 mg/d 492 mg/d Each group was further divided into two subgroups, receiving either 110% or 120% of their Maintenance Energy Requirement (MER), which was evaluated in a metabolic chamber at baseline

More recently, complementary studies examined the associations between levels of IGF-1 in the blood and the chances of the disease developing in 206,263 women enrolled in the UK Biobank [64]

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