NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)
Chronic use is associated with tolerance, withdrawal, and memory disturbances
Food and Drug Administration for nonantimicrobial sulfonamides may include warnings about possible cross-reaction with antimicrobial sulfonamides, 1 these drugs do not need to be withheld
The general principle also applies to all GLP-1 injections , not just tirzepatide
Read on as we look at these symptoms in more detail in the next section
5.4 Other metabolites In addition to short-chain fatty acids, bile acids, and tryptophan metabolites, numerous other gut microbial metabolites are implicated in the pathogenesis of PCOS