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These may include: Nausea and stomach upset Diarrhea Constipation Injection site redness or swelling Itching Headache Dizziness Blood clots Swelling In rare cases, some people may experience an allergic reaction to vitamin B12, which can cause symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat

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To overcome the short half-life and frequent subcutaneous administration of pramlintide, new amylin receptor agonists like cagrilintide have been developed

Retatrutide also covers GLP-1 and GIP (the same receptors tirzepatide hits), so it overlaps