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While identification of the different molecular signatures and genotypes among responders and non-responders may help develop predictive biomarkers to enable patient stratification in clinical setting, the molecular and genetic heterogeneity in many tumors is still a big challenge for successful cancer therapy [182]

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Importantly, while GLP-1 inhibits glucagon release to reduce hepatic glucose output, GIP can stimulate glucagon secretion under certain conditions, such as low glucose states, which may represent an adaptive mechanism to maintain glucose supply during fasting or stress 3

Promotes Early Detection: Helps find cancers before symptoms arise, potentially improving treatment outcomes