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Caution is advised for people with a history of pancreatitis, diabetic retinopathy, uncontrolled hypertension, or severe kidney or liver disease, and pregnancy status should be confirmed first

Based on these findings, PIONEER 6 supports preliminary cardiovascular safety for the treatment of T2DM

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As a weekly injection targeting GLP-1 and GIP hormones, Zepbound has proven effective, with users losing an average of 20.9% body weight in trials