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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

Placental inflammation can induce oxidative stress, resulting in an overproduction of free radicals/ROS and reduced antioxidant ability ( Figure 4 ) (113)

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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above

Hormesis: Beneficial adaptations to low-dose stress like heat, cold, or fasting