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A kinome screen reveals that nemo-like kinase is a key suppressor of hepatic gluconeogenesis

The risk of lean mass loss during rapid weight reduction on tirzepatide is a particular concern for autoimmune patients who may already have muscle wasting from disease activity, corticosteroid use, or reduced physical activity during flares

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Note that if you have heart failure or kidney disease, you should follow your healthcare provider's specific advice about fluid intake

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Patients should be evaluated for iron deficiency with serum ferritin levels and transferrin saturation, as iron supplementation can improve symptoms when ferritin is below 75 ng/mL and/or transferrin saturation is below 20%