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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

Bifidobacterium lactis BL-99 protects against colitis-induced OP in mice by modulating GM, restoring intestinal barrier integrity, and inhibiting inflammation (145) ( Figure 4 , Table 3 )

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Its primary research value lies in its ability to activate the GLP-1 receptors located in the pancreas, stomach, and brain, allowing scientists to map the systemic effects of sustained incretin activation on metabolic homeostasis

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