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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione
6 Preventable Risk Factors Associated With Heart Attacks
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In addition, knocking down ACTL6A increased the expression levels of prostaglandin-endoperoxide synthase 2 (PTGS2) (Supplementary Fig 3b), which is a ferroptosis marker 30,46
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