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The MK-677 story is in fact the textbook illustration of this gap: the biomarker moved reliably and substantially in every population studied, yet the clinical endpoints those biomarkers were supposed to predict cognition, functional performance, strength did not

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Notably, the acetylation-defective mutant p53 3 KR, which cannot induce cell-cycle arrest, senescence or apoptosis, fully retains the ability to suppress SLC7A11 and trigger ferroptosis under oxidative stress (Le et al., 2015)

Although it constitutes a broad-spectrum antiviral medication, IFN does not immediately kill or suppress an infiltrating virus

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Sterility and proper technique are crucial