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This activation is mediated, at least in part, by the NF-B signaling pathway

More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings

Conversely, tectorigenin (TEC) leverages tRF-31R9J to recruit HDAC1, which in turn reduces histone lactylation and acetylation of ferroptosis-related genes, inhibiting hepatocyte ferroptosis and ameliorating non-alcoholic fatty liver disease[211]

Rohani, M