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To ensure energy balance, the brain must balance energy expenditure and conservation in coordination with internal metabolic statesdynamic regulation of motivational cognition may represent a higher-order mechanisms by which energy-expending behaviour is aligned with energy allostatic goals

This pattern aligns with higher effective immune escape in summer 2024 and lower in winter, differing from the model's assumption of constant annual escape

These results surpass those of other weight loss drugs, such as semaglutide, which resulted in an average weight reduction of approximately 15% over the same period

GLP-1RAs and other incretin-based NuSHs, by ameliorating hepatic lipotoxicity, improving insulin sensitivity, and reducing inflammation, may help restore a more functional immune milieu