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For stretch marks specifically, clinical protocols typically target: 1.5mm to 2.0mm for active striae rubrae on body areas with thicker dermis 2.0mm to 2.5mm for mature striae albae where deeper dermal remodeling is necessary Shallower passes (0.5mm-1.0mm) over the outermost stratum for surface texture improvement and serum infusion These settings are not fixed prescriptions a skilled practitioner adjusts depth in real time based on tissue response, patient comfort, and treatment area

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Accordingly, this research elucidates novel mechanisms underlying the antidepressant efficacy of ESC and highlights the pivotal importance of the microbiota-gut-brain axis in mediating these effects