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However, up to 40% of patients do not achieve satisfactory relief, prompting investigation of combination therapy, most commonly adding a second agent (e.g., duloxetine plus pregabalin), which can yield incremental pain reduction of 1020% but with increased risk of sedation, dizziness and drug interactions [64]

The results of the study say that spironolactone reduces the symptoms of hirsutism by about 40% and shows efficacy in 50% of treated individuals when used as monotherapy (132)

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Carnitine transport mediated by OCTN2 is Na+ dependent