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Variants in MTHFR , MTRR , and COMT influence methylation throughput, B12 handling, and methyl-group clearance, the very systems MIC-B12 engages
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The relationship between B12 and bowel changes is typically indirect, relating more to the supplement formulation, excipients (inactive ingredients), or underlying health conditions rather than the vitamin itself
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Sixteen studies were included in the quantitative synthesis, comprising a total of 6,098 participants