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The binding affinity of icodec and semaglutide to HSA was investigated by measuring the displacement of icodec and semaglutide from HSA in vitro at increasing concentrations of a soluble fatty acid derivative (SFAD) consisting of a 20-carbon long fatty acid with a 4 -Glu extension, similar to the side chains on icodec and semaglutide
The IC 50 was calculated by fitting the % Inhibition values and log values of compound concentrations to a nonlinear regression equation (dose response - variable slope) using GraphPad 8.0
4, May 2009, pp
Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection
To our knowledge, our study is the first associating semaglutide treatment with transcriptomic signatures relating to alterations of the circadian rhythm
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