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They slow gastric emptying, reduce hunger signals, and quiet the neurological food noise that many patients have lived with for years
Moreover, both HFD and caloric restriction stimulate peroxisome proliferator-activated receptors (PPAR)- and associated pathways, which produce acetyl-CoAs essential for ketogenesis and supply substrates for energy metabolism, hence supporting intestinal development
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Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG et al
Compared to individuals without steatosis, patients with NASH have an increased incidence of ASCVD (HR 1.37, 95% CI 1.101.72) [102] and fatal and nonfatal MACEs (OR: 1.64, 95% CI 1.262.13) [103]