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The dual agonist mechanism distinguishes tirzepatide from earlier GLP-1 receptor agonists such as semaglutide or dulaglutide

[DOI] [PubMed] [Google Scholar] 71.abuzek K., Kozowski M., Szkudapski D., Sikorska P., Kozowska M., Okopie B

However, it is documented in the prescribing information that patients treated with GLP-1 receptor agonists report gastrointestinal adverse events at a significantly higher rate than patients treated with a placebo

But in the two semaglutide plus trevogrumab groups, this percentage was 17%, while people in the full combination group saw just a 7% loss of lean body mass

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