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Moreover, the visual assessment results and subjective evaluations reports revealed a statistically significant increase in the whitening efficacy of niacinamide after 4 and 8 weeks of therapy compared to the baseline (Lee et al., 2016b)

Myostatin (GDF-8), a member of the TGF-beta superfamily, is a negative regulator of muscle mass that signals through SMAD transcription factors and tends to oppose the Akt/mTOR-driven hypertrophic program that IGF-1 promotes

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