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Our work herein identifies a key role for MC-derived histamine release and subsequent H4R activation in driving clinical and histopathologic severity in UC-like inflammation by regulating innate neutrophil recruitment and associated mucosal injury, likely via coordinating the downstream local production of IL-6 and neutrophil-attracting chemokines

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Although there is no definitive research conclusion, attention should also be paid to the potential adverse consequences of carnitine deficiency for infants, which could even lead to pathological changes

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