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These genes have varying impacts on RA onset, with the HLA-DRB1 gene being widely acknowledged as the primary susceptibility gene for RA in certain populations [28]

Using the Broad Institute's Connectivity Map (CMap), which compares gene expression signatures across thousands of compounds, Pickart et al

However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data

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