A big study in the New England Journal of Medicine found that people taking semaglutide had an average weight loss of 14.9% from their starting weight, including data from healthy subjects
As part of the design, patients initially in the comparator group could enter the combination group, but only after receiving the add-on drug
These participants also had a history of at least one unsuccessful dietary effort to lose weight
Dose increases commonly bring a temporary return of GI side effects
And while in most people with HIV traditional risk factors are driving their fatty liver disease, we do think there is a component of liver disease that is HIV specific, so some of those secondary effects of semaglutide may have unique benefits in people with HIV. Lake and colleagues enrolled 49 adults with MASLD and HIV into the open-label phase 2b SLIM LIVER study
If reactions persist or worsen, it could indicate an issue with the reconstituted solution, the injection technique, or an allergy to a component like benzyl alcohol
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