Likewise, recent comparative studies in sporadic (icv-STZ Mouse) and familial (3xTg-AD mouse) mice models of AD have revealed the transcriptional alteration of more than 80 genes related to synapse function, apoptosis and autophagy, AD-related protein kinases, glucose metabolism, insulin signaling, and mTOR pathway in the hippocampus and the cerebral cortex, not only when compared to WT animals, but also between both AD models (Chen et al., In summary, we hypothesize that by upregulating Gpx4 gene expression and increasing GPx4 protein levels and enzyme activity, DHA initiates a self-protective biochemical strategy in the hippocampal neuron to control non-enzymatic peroxidation of DHA-containing phospholipids in the membrane from cellular and subcellular compartments
Always direct the needle toward the glass wall
nidulans wild-type and A
The RNA isolation and quantitative RT-PCR were performed as described earlier (Choi Protein S-glutathionylation and protein content in tissue and cells were assayed by Western blot analysis as described (Han Liver frozen sections and cells were performed as described previously (Seidel The data presented in the charts and tables are expressed as the mean standard error of the mean (SEM)
Qiu, M., Chen, J., Li, X
Phenylalanine and tyrosine contribute to the production of dopamine and norepinephrine, which affect concentration, resilience under stress and mental clarity
