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26 Statins were initiated in 380 patients in that study and 159 patients in the 25 mg OCA group, but cardiovascular outcomes were not different between the groups

Supporting the protective role of NRF2 in type 1 diabetes, Nrf2 / mice exhibited more pancreatic -cell damage in an alloxan-induced model of type 1 diabetes (91) as well as increased serum triglycerides, higher blood glucose levels, and increased hepatic gluconeogenesis compared with Nrf2 +/+ mice following STZ injection (92)

Zhang Z, Jia J, Lai Y, Ma Y, Weng J, Sun L

doi: 10.3390/pr11051459 157

They found instead that the TIP peptide delivered directly to the kidneys not only reduced inflammation but actually decreased blood pressure, even in the face of a high-salt diet, and without interfering with the infection-fighting role of TNF