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10.1080/15548627.2022.2124499[Epub ahead of print]

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JAMA Netw Open 2024;7:e2350408.ArticlePubMedPMC 63

Atlanta, GA, Centers for Disease Control and Prevention, U.S

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Short half-life = faster clearance shorter cycles possible Long half-life (long esters) = takes longer to reach stable blood levels longer cycles required For example: Testosterone Propionate (short ester) 68 week cycles common Testosterone Enanthate / Cypionate (Testosterone Enanthate) 1016 weeks preferred Boldenone Undecylenate (Equipoise) (Equipoise vs Anavar) needs 1216 weeks minimum to shine due to very long ester Cycle duration should reflect compound half-life to allow for full therapeutic window and stabilization of blood concentrations. Garevik et al., Journal of Internal Medicine Anabolic / Androgenic Potency More potent, fast-acting compounds (like Trenbolone or Superdrol ) dont need and shouldnt be run for long cycles