ro compounded glp-1 Eli Lilly strikes Zepbound deal with Ro, amid questions on GLP-1s Ro Weight Loss: Step-by-Step Guide

doi: 10.1111/dom.14725

And recent research published in JAMA Network Open suggests older adults are more likely than their younger peers to discontinue these popular medications

NICE in the UK recommends a maximum of two years for semaglutide (Wegovy), though no such limit exists for tirzepatide (Mounjaro)

Working with your provider, he says, can keep you on the right track

Someone stopping these medications doesnt have the same control over their obesity, and their weight can increase. What to expect Nearly 12% of Americans about one in eight have used GLP-1 drugs for weight loss, according to a 2025 report from RAND, a nonprofit research organization

The clinical trial evidence on duration The landmark STEP trials for semaglutide and SURMOUNT trials for tirzepatide provide the clearest data on what happens at different treatment durations