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Acknowledgements This work was supported in part by grants AI 048,079, AI 072,648, and AT004332 from the National Institutes of Health, the Alliance for Lupus Research, and the Central New York Community Foundation

However, B12 injections are not a treatment for insomnia, depression, or anxiety on their own

99 However, knockdown of bromodomain-containing protein 4 (BRD4), an essential member of the bromodomain and extra-terminal domain (BET) family and epigenetic reader, markedly reduces H4K8la level, increasing A1 polarization in astrocytes and promoting neuronal death by pro-inflammatory factors such as IL-6, IL-1, and TNF-

Mild side effects, such as redness or irritation at the injection site, are rare and typically resolve on their own

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BPC-157 is not FDA-approved for any use