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Measuring homocysteine may help to identify bottlenecks in the methionine cycle and related pathways, informing the use of appropriate, targeted and personalised interventions to alleviate restricted function for an individual

However, it may fail to correctly identify 1a and 1b subtypes in a variable percentage of cases (514%) 15,16,17,18 , and tends to misclassify genotype 6 as genotype 1 16,23

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