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[160] Research and emerging applications [edit] A 2014 meta-analysis found that semaglutide may be effective in lowering liver enzymes (transaminitis) and improving certain radiologically observed features of metabolic dysfunctionassociated steatotic liver disease

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Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the hypothalamic arcuate nucleus, the area postrema, the nucleus tractus solitarius, and vagal afferent neurons

Pancreatitis: Severe abdominal pain, nausea, and vomiting may indicate inflammation of the pancreas

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The coprimary endpoints of the trial were the percentage change in body weight and achieving a weight reduction of at least 5% at 68 weeks for semaglutide 2.4 mg versus placebo, assessed by intention to treat