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The production of ROS is linked to the overexpression of a misfolded disulphidebonded protein, carboxypeptidase Y (CPY * )

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Rossato JI, Bevilaqua LRM, Izquierdo I, Medina JH, Cammarota M (2009) Dopamine controls persistence of long-term memory storage

The safety profile of cagrilintide-semaglutide was broadly consistent with that reported for other incretin-based therapies, although gastrointestinal adverse events and treatment discontinuations occurred more frequently than with either semaglutide or cagrilintide alone, highlighting the importance of careful patient selection and long-term adherence

Accordingly, the interaction between cells of the BBB and microglia is an emerging field of interest, particularly in the context of systemic diseases and viral infections that indirectly impact immune responses in the brain through endothelial and microglia cell activation