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off-label prescribing differed between the drugs approved for T2DM (Ozempic and Mounjaro) and those approved for weight loss (Wegovy)

Cell Metab 19(2):302309 Lee HJ, Lee JO, Kim N, Kim JK, Kim HI, Lee YW, Kim SJ, Choi J-I, Oh Y, Kim JH, Hwang S, Park SH, Kim HS (2015) Irisin a novel myokine, regulates glucose uptake in skeletal muscle cells via AMPK

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2005) found that activating GLP-1 receptors decreased testosterone production in an experimental model, raising concern that GLP-1 agonism could theoretically impair Leydig cell function