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It was found that the stiffening of the ECM impaired the differentiation of alveolar type II (AT2) epithelial cells into type I (AT1) cells 13,14 , which damaged the self-repairing abilities of alveolar structure

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However, Hagen and Jones reported an increase in plasma glutathione levels in four out of five subjects after a single oral dose of 15 mg/kg body weight

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