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Retaining the solution for about 15 minutes is typically recommended before releasing it
Situmbeko Liweleya, Emmanuel Luwaya, Hanzooma Hatwiko, Lukundo Siame, Propheria Cheelo Lwiindi, Taonga Tembo, and Chileleko Siakabanze edited and reviewed the manuscript
10.1093/cercor/bhp067 Cereb

For sexual exposure to a person with acute hepatitis B, a single dose of Hepatitis B Immune Globulin (Human) is 75% effective if administered within 2 weeks of last sexual exposure.(9) Since infants have close contact with primary care-givers and they have a higher risk of becoming HBV carriers after acute HBV infection, prophylaxis of an infant less than 12 months of age with Hepatitis B Immune Globulin (Human) and hepatitis B vaccine is indicated if the mother or primary care-giver has acute HBV infection.(9) Administration of Hepatitis B Immune Globulin (Human) either preceding or concomitant with the commencement of active immunization with Hepatitis B Vaccine provides for more rapid achievement of protective levels of hepatitis B antibody, than when the vaccine alone is administered.(17) Rapid achievement of protective levels of antibody to hepatitis B virus may be desirable in certain clinical situations, as in cases of accidental inoculations with contaminated medical instruments.(17) Administration of Hepatitis B Immune Globulin (Human) either 1 month preceding or at the time of commencement of a program of active vaccination with Hepatitis B Vaccine has been shown not to interfere with the active immune response to the vaccine.(17) HyperHEP B is made from human plasma

krlec, K., Ruman, R., Jarc, E., Sikiri, P., vajger, U., Petan, T., Perii Nanut, M., trukelj, B., & Berlec, A