Cytoplasmic restriction of mutated SOD1 impairs the DNA repair process in spinal cord neurons
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Microsomal prostaglandin E 2 synthase-1 (MPGES-1), a member of the MAPEG family, is implicated in the biosynthesis of prostaglandin E 2 a metabolite of arachidonic acidinvolved in several biological functions
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Furthermore, the lack of molecular indicators of angiogenesis or barrier compromise in this model raises compelling questions about the molecular thresholds and contextual signals required to initiate vascular changes during progressive neuronal loss (Thomsen et al