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half-life: ~30 min2 hours Plasma levels decline ~60% with age (~200 ng/mL at age 20 ~80 ng/mL at age 60) Influences expression of ~31% of studied human genes linked to repair and regeneration Stimulates collagen type I and III synthesis by up to 70% in studied models Activates fibroblasts

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Chaouhan HS, Vinod C, Mahapatra N, Yu S-H, Wang I-K, Chen K-B, et al